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Abnormal Embryos
 

 All the HDBR embryos are genotyped at collection. The majority of the samples reflect the 46XX or 46 XY karyotype, however a small percentage are found to be karyotypically abnormal.

The movies below show volume renders of OPT models of karyotypically abnormal embryos. No staining has been used on the specimens, the images were captured using autofluorescence with a FITC filter.

Triploidy

   
Sample 676 CS13 - Karyotype 69, XXY   Sample 1235 CS16 - Karyotype 69, XXX   Sample 675 CS17 - Karyotype 69, XXX
This embryo has a marked neural tube defect.    

 

Down's Syndrome

   
Sample 729 CS11 - Karyotype 47, XX+21 Sample 221 CS17 - Karyotype 47, XY +21
  This embryo has a very immature heart.

 

Turner's Syndrome

   
Sample 938 CS14 - Karyotype 45X Sample 904 CS16 - Karyotype 45X
   

 

Normal karyotype with neural tube defect

   
Sample 354 CS13 - Karyotype 46, XX   Sample 274 CS13 - Karyotype 46, XY   Sample 205 CS19 - Karyotype 46, XX
     

 

Other models of embryos with abnormal karyotypes:

Karyotype

Syndrome

Stages available

45, X Turners CS12, CS14 (shown above), CS16 (shown above), CS19, CS22, 11PCW
47, XX +21 or 47, XY +21 Downs CS11(shown above), CS12, CS16, CS17 (shown above), CS18
47, XXY Kleinfelters CS19
47, XX +13 Patau Stage unknown - Growth distortion
47, XX +14 Trisomy 14 CS12
47, XY +15 / 46,XY Trisomy 15 Stage unknown - Growth distortion
47, XX +16 or 47, XY +16 Trisomy 16 Stages unknown - Growth distortion
47, XX +18 Edwards CS17
47, XX +22 Trisomy 22 CS10
48, XY +5 +8/ 46 XY   CS12
69, XXY Triploidy CS13, CS16, CS17 (all shown above), CS22, CS23
46, XY or 46, XX Normal karyotype with neural tube defect CS13 (shown above), CS15, CS17, CS18, CS19 (shown above)

 

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