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Carnegie Stages 11 and 12

The movies below show volume renders of OPT models. No staining has been used on any of the specimens and the images were captured using autofluorescence with a FITC filter.

 

CS11 N285 46XX

CS11 N662 46XX

 

CS12 N476 46XX

CS12 N288 46XX

 

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Carnegie Stage 12

The movies below show anatomical domains defined in the N288 and N476 models. The domains have been manually defined in the OPT models using specialised software and then visualised using commercial rendering packages.

The various domains are: neural tube - orange; heart - red; liver - dark green; optic vesicle - dark blue; otic vesicle - yellow; dermatomes - cyan.

 

N288 46XX

N476 46XX

 

 

 

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Carnegie Stage 12 Definition

 

Age is approximately 26 postovulatory days Length is approximately 3-5 mm External Features Include: a characteristic curved posture, three pharyngeal arches are visible, the caudal neuropore is closing or closed; the otic vesicles are almost closed but not detached; the upper limb buds are beginning to appear. O'Rahilly R and Muller F [1987] Developmental Stages in Human Embryos. Carnegie Institute, Washington, Publication no. 637