Investigating the vertical transmission of SARS-CoV2

 

The gene expression data below has been kindly submitted by Dr Mattia Gerli at the UCL Great Ormond Street Institute of Child Health.

The localisation of ACE2 (red) and TMPRSS2 (brown) has been studied in a variety of fetal tissues from 14PCW to 22PCW.
Co-expression of these two proteins is known to be a prerequisite for SARS-CoV-2 infection.

Please click here for the original publication.

 

Click on the images below to enlarge

 

 

Intestine

14PCW

sars-cov-2 gene expression in a human fetus

18PCW

sars-cov-2 gene expression in a human fetus

20PCW

sars-cov-2 gene expression in a human fetus

22PCW

sars-cov-2 gene expression in a human fetus

22PCW X40

sars-cov-2 gene expression in a human fetus

 

 

Lung

sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus

 

 

Kidney

sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus

 

 

Bladder

sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus
blank
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus

 

 

Skin

sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus

 

 

Amniotic membrane

sars-cov-2 gene expression in a human fetus
blank
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus

 

 

Placenta

sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus
sars-cov-2 gene expression in a human fetus